Nicorandil CAS NO.65141-46-0

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Nicorandil Basic information

Product Name:	Nicorandil
Synonyms:	n-[2-(nitroxy)ethyl]-3-pyridinecarboxamide;N-[2-(NITROOXY)ETHYL]-3-PYRIDINECARBOXAMIDE;NICORANDIL;PERISALOL;SIGMART;IKOREL;ADANCOR;2-nicotinamidoethylnitrate
CAS:	65141-46-0
MF:	C8H9N3O4
MW:	211.17
EINECS:	265-514-1
Product Categories:	Pharmaceutical;Intermediates & Fine Chemicals;Pharmaceuticals;Potassium channel;Aromatics;Heterocycles;Ikorel;reagent;Cardiovascular APIs
Mol File:	65141-46-0.mol

Nicorandil Chemical Properties

mp	92°C
storage temp.	Desiccate at +4°C

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MSDS Information

Nicorandil Usage And Synthesis

Chemical Properties	White solid
Usage	An antianginal
Usage	Antihypertensor
Biological Activity	K ATP channel opener and NO donor, clinically used as antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K ATP channels (EC 50 values are 10 and > 500 mM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

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